货号：AB10553

品牌：Merck Millipore

规格：100Ug

目录价：￥4810.00

市场价格：￥4088.50

会员价格：￥3848.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Prohormone Convertase PC1/PC3 Antibody | AB10553 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Prohormone Convertase PC1/PC3. View All» Molecular Weight: Observed at 95 KDa because of multiple glycosylation. View All» Epitope: Mature Chain View All» Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated linear peptide within human Prohormone Convertase PC1/PC3. View All» Background Information: The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse and rat. Predicted to react with pig based on sequence homology. Ape, dog, and rat (97%). Bovine (95%). View All» Application Notes: Immunocytochemistry Analysis: 1: 500 dilution from a previous lot detected Prohormone Convertase PC1/PC3 in HeLa, C2C12, NIH/3T3 cell lysates. View All» Control: Mouse adrenal gland tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse adrenal gland tissue lysate.Western Blot Analysis: : 0.5 µg/mL of this lot detected Prohormone Convertase PC1/PC3 on 10 µg of mouse adrenal gland tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 12 months. View All» UniProt Number: P29120 View All» Entrez Gene Number: NM_000439.3 View All» Gene Symbol:
  • BMIQ12

  • EC 3.4.21.93

  • NEC1

  • PC1

  • PC3

  • SPC3
    View All» Alternate Names:
    • NEC 1

    • Prohormone convertase 1

    • Proprotein convertase 1

    • neuroendocrine convertase 1

    • prohormone convertase 3

    • proprotein convertase subtilisin/kexin type 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.CATALYTIC ACTIVITY: Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.COFACTOR: Calcium.SUBCELLULAR LOCATION: Cytoplasmic vesicle › secretory vesicle. Note: Localized in the secretion granules.POLYMORPHISM: Genetic variations in PCSK1 define the body mass index quantitative trait locus 12 (BMIQ12) [MIM:612362]. Variance in body mass index is a susceptibility factor for obesity.INVOLVEMENT IN DISEASE: Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency) [MIM:600955]. PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.SEQUENCE SIMILARITIES: Belongs to the peptidase S8 family. Furin subfamily. View All» Product Name: Anti-Prohormone Convertase PC1/PC3 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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