货号：AB10556

品牌：Merck Millipore

规格：100UL

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-mGluR8 Antibody | AB10556 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes mGluR8. View All» Molecular Weight: 101 kDa View All» Epitope: Cytoplasmic Domain View All» Immunogen: This antibody is generated from guinea pigs immunized with a KLH-conjugated linear peptide selected from residues corresponding to the cytoplasmic domain of rat mGluR8. View All» Background Information: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. View All» Species Reactivity: Rat View All» Species Reactivity Note: Predicted to react with human, chimpanzee, monkey, dog, cow and mouse based on 100% sequence homology. View All» Application Notes: Evaluated by Western Blot in rat brain lysate. Although intended for use in IHC analysis, a band was observed at ~101kDa. View All» Control: Rat brain lysate View All» Quality Assurance: Immunohistochemistry Analysis: : 1:100-500 dilution from a previous lot detected mGluR8 on rat brain tissue. View All» Purification Method: Unpurified View All» Presentation: Unpurified guinea pig polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O00222 View All» Entrez Gene Number: NP_000836.2 View All» Gene Symbol:

• GLUR8

• mGlu8

• GPRC1H

• MGLUR8

• FLJ41058

• MGC126724

• GRM8
  View All» Alternate Names:
  • glutamate metabotropic receptor 8

  • glutamate receptor

  • metabotropic 8
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene View All» UniProt Summary: FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.SUBUNIT STRUCTURE: Interacts with PICK1 By similarity.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family. View All» Product Name: Anti-mGluR8 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Guinea Pig View All»
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