货号：AB10613

品牌：Merck Millipore

规格：

目录价：￥4657.00

市场价格：￥3958.45

会员价格：￥3725.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PSMA (N-Terminal) Antibody | AB10613 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes PSMA (N-Terminal). View All» Immunogen: Synthetic peptide derived from the N-terminus of human PSMA. View All» Background Information: PSMA (prostate specific membrane antigen) is a type II, integral membrane glycoprotein, composed of a 19 amino acid intracellular domain containing the N-terminus, a 24 amino acid transmembrane region, and a 707 amino acid extracellular C-terminal domain. The PSMA gene has been cloned and sequenced, and has been localized to chromosome 11q. PSMA is highly expressed in prostate secretory-acinar epithelium, in some benign extraprostatic epithelial cells from breast, duodenum, and kidney tissues, and in prostate cancer. On the basis of its highly prostate-specific nature, PSMA has been used as a prostate cancer marker antigen and diagnostic target for prostate cancer detection. Recently, evidence of limited and specific endothelial PSMA expression has been discovered: the neovasculature of a wide variety of malignant neoplasms (lung, colon, breast, etc.) demonstrates PSMA expression. This finding suggests that PSMA may be an effective target for monoclonal antibody-based anti-neovasculature therapy. PSMA has also been identified in the human nervous system. Based on activity, immunoreactivity, and mRNA sequence comparison with one form of NAALADase, a neuropeptide that may modulate glutaminergic transmission in the nervous system, PSMA was found to be indistinguishable from NAALADase derived from human cerebellar cell isolates. Therefore, the form of NAALADase also known as PSMA is expressed in brain, where it makes up a significant fraction of brain NAALADase activity. View All» Species Reactivity: Human View All» Species Reactivity Note: Human (positive control: LNCaP FGC cells) View All» Application Notes: Western Blotting: 1-3 μg/mL View All» Purification Method: Immunoaffinity purified View All» Presentation: This polyclonal antibody is supplied as a 400 μL aliquot in phosphate buffered saline (pH 7.4) containing 0.1% sodium azide. View All» Storage Conditions: Store at -20°C in undiluted aliquots for 1 year from date of shipment. View All» UniProt Number:

• P25786

• P25787

• P25788

• P28066

• P60900

• O14818
  View All» Entrez Gene Number:
  • NM_002786.2

  • NM_148976.1
    View All» Gene Symbol:
    • PSMA1

    • MGC22853

    • MGC14751

    • PROS30

    • HC2

    • PROS-30

    • MGC1667

    • MGC21459

    • PSC2

    • MGC14542

    • MGC23915

    • NU

    • MGC14575
      View All» Alternate Names: Prostate Specific Membrane Antigen View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. View All» UniProt Summary: FUNCTION: SwissProt: P60900 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.SIZE: 246 amino acids; 27399 Da SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure.SUBCELLULAR LOCATION: Cytoplasm. Nucleus.SIMILARITY: SwissProt: P60900 ## Belongs to the peptidase T1A family. View All» Brand Family: Chemicon View All» Product Name: Anti-PSMA (N-Terminal) Antibody | AB10613 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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