货号：AB10615

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDEF Antibody | AB10615 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes PDEF. View All» Immunogen: Synthetic peptide derived from the internal region of human PDEF (prostate-derived Ets factor). View All» Background Information: PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors. View All» Species Reactivity: Human View All» Species Reactivity Note: Human (positive control: LNCaP cells) View All» Application Notes: ELISA: 0.1-1μg/mL Western Blotting: 1-3 μg/mL View All» Purification Method: Immunoaffinity purified View All» Presentation: This polyclonal antibody is supplied in 400 μL of phosphate buffered saline (pH 7.4) containing 0.1% sodium azide. View All» Storage Conditions: Store at -20°C in undiluted aliquots for 1 year from date of shipment. View All» UniProt Number: O95238 View All» Entrez Gene Number: NM_012391.1 View All» Gene Symbol:

• SPDEF

• bA375E1.3

• PSE

• PDEF

• RP11-375E1__A.3
  View All» Alternate Names: Prostate-derived Ets Factor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: O95238 # May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.SIZE: 335 amino acids; 37518 Da SUBUNIT: Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1.SUBCELLULAR LOCATION: Nucleus (Probable).TISSUE SPECIFICITY: Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.SIMILARITY: SwissProt: O95238 ## Belongs to the ETS family. & Contains 1 ETS DNA-binding domain. & Contains 1 PNT (pointed) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-PDEF Antibody | AB10615 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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