货号：AB10621

品牌：Merck Millipore

规格：

目录价：￥5066.00

市场价格：￥4306.10

会员价格：￥4052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SUMO-3 Antibody | AB10621 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes SUMO-3. View All» Immunogen: Synthetic peptide derived from the C-terminal region of the human SUMO-3 protein. View All» Background Information: Small ubiquitin-related modifier proteins (SUMO-1, SUMO-2 and SUMO-3) are members of the ubiquitin-like protein family. SUMO-3 regulates Amyloid β generation and may be critical in the onset or progression of Alzheimer's disease. SUMO-2/3 forms poly-(SUMO) chains, which is conjugated to topoisomerase II and APP and regulates chromosomal segregation, progression of Alzheimer's disease and cellular responses to environmental stress. SUMO-1, 2, and 3 proteins localize to the nuclear membrane, nuclear bodies, and cytoplasm, respectively. View All» Species Reactivity: Human View All» Species Reactivity Note: Human (positive control: SK-OV3, Jurkat cell lysates) View All» Application Notes: Western Blotting: 1-3 μg/mL View All» Purification Method: Immunoaffinity purified View All» Presentation: This polyclonal antibody is supplied in 400 μL of phosphate buffered saline (pH 7.4) containing 0.1% sodium azide. View All» Storage Conditions: Store at -20°C in undiluted aliquots for 1 year from date of shipment. View All» UniProt Number: P55854 View All» Entrez Gene Number: NM_006936.2 View All» Gene Symbol:

• SUMO3

• SMT3H1

• SMT3A

• SUMO-3

• SUMO-2
  View All» Alternate Names: Small Ubiquitin-related Modifier Protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P55854 # Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.SIZE: 103 amino acids; 11637 Da SUBUNIT: Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Expressed predominantly in liver.PTM: Polymeric chains can be formed through Lys-11 cross-linking. & Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.SIMILARITY: SwissProt: P55854 ## Belongs to the ubiquitin family. SUMO subfamily. & Contains 1 ubiquitin-like domain. View All» Brand Family: Chemicon View All» Product Name: Anti-SUMO-3 Antibody | AB10621 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-151642.htm
  © Merck Millipore代理AB10621 Rb X SUMO-3 Polyclonal Antibody，产品报价联系微信jinshanbio