货号：AB10622

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CUL-5/VACM-1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes CUL-5/VACM-1. View All» Immunogen: Synthetic peptide derived from an internal region of the human, mouse, rat, rabbit, and orangutan CUL-5/VACM-1 proteins. View All» Background Information: CUL-5/VACM-1 (cullin-5, vasopressin-activated calcium mobilizing receptor 1) is one component of the ECS (elongin B/Ccul2/cul5-SOCS box protein) complex that forms an E3 ubiquitin ligase that covalently binds ubiquitin to proteins targeted for degradation via the proteasome. CUL-5 is ubiquitously expressed in the central nervous system and in many peripheral organs. Human immunodeficiency virus-1 (HIV-1) protein Vif forms a Skp1-cullin-F-box (SCF)-like complex with CUL-5/VACM-1 and Elongins B and C. The ability of Vif to suppress the antiviral activity of APOBEC3G, which induces hypermutations in newly synthesized viral DNA, is specifically dependent on CUL-5-SCF function, as it allows Vif to interact with APOBEC3G and induce its ubiquitination and degradation. The CUL-5-SCF pathway used by Vif is thus a potential target for antiviral development. The CUL-5 gene product is also know as VACM-1. Unlike the membrane-integrated AVP receptors or the cytosolic/nuclear cul-1 and cul-2 proteins, the VACM-1 protein can be either nuclear/cytosolic or a cell membrane protein. CUL-5/VACM-1 inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways. In rabbits, mRNA is expressed in kidney medulla, brain, heart and ovaries. In human tissues expression in kidney, brain, heart, placenta, and skeletal muscle is observed. The expression of CUL-5/VACM-1 is dependent on the cell cycle. This protein virtually disappears during the S phase and localizes to the cytosol during cell division and to the cell membrane at the completion of cytokinesis in rat adrenal medulla endothelial cells. CUL-5/VACM-1 is also expressed in both breast epithelial cells and breast cancer cells. 82% of breast cancers demonstrate decreased CUL-5/VACM-1 expression versus matched normal tissues. This finding supports the hypothesis that decreased expression of CUL-5/VACM-1 may play a role in breast tumorigenesis. Further evidence for this finding is observed in T47D breast cancer cells in which overexpression of CUL-5/VACM-1 significantly attenuates cellular proliferation and MAPK phosphorylation when compared to control cells. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human, Rat (positive controls: MCF-7, MDA-MB-231, and HEK 293T cell lysates, rat brain homogenates). Based on sequence identity, reactivity with mouse, rabbit, and orangutan is also expected. View All» Application Notes: Western Blotting: 2 μg/mL View All» Purification Method: Immunoaffinity purified View All» Presentation: This polyclonal antibody is supplied in 400 μL of phosphate buffered saline (Ph 7.4) containing 0.1% sodium azide. View All» Storage Conditions: Store at -20°C in undiluted aliquots for 1 year from date of shipment. View All» UniProt Number: Q93034 View All» Entrez Gene Number: NM_003478.3 View All» Gene Symbol:
  • CUL5

  • VACM-1

  • Cullin-5

  • CUL-5

  • VACM1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q93034 # Component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.SIZE: 780 amino acids; 90955 Da SUBUNIT: Part of E3 ubiquitin ligase complexes with elongin BC complex (TCEB1 and TCEB2), RBX1 and a substrate adapter protein that can be either MUF1, SOCS1, TCEB3, VHL or WSB1. Substrate adapter protein can be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. Interacts also with RNF7/RBX2.PTM: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).SIMILARITY: SwissProt: Q93034 ## Belongs to the cullin family. View All» Brand Family: Chemicon View All» Product Name: Anti-CUL-5/VACM-1 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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