货号：AB10623

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IL-4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes IL-4. View All» Immunogen: Purified recombinant swine IL-4. View All» Background Information: This antibody recognizes natural and recombinant swine IL-4.129 AA (~20 kDa) protein with three disulfide bonds that are critical for biological activity. IL-4 is glycosylated but this is not required for biological activity. View All» Species Reactivity: Pig View All» Species Reactivity Note: Recognizes recombinant swine IL-4. View All» Application Notes: This antibody has been used in Western and Dot blot applications. For Dot blot applications, a 1:100 dilution of the antibody will readily detect 5 ng of protein. View All» Purification Method: Protein G purfied View All» Presentation: Purified immunoglobulins in phosphate buffered saline, pH 7.3. Contains no preservatives. The endotoxin level is <0.1 ng/μg of protein. View All» Storage Conditions: Store at -20°C in undiluted aliquots for 1 year from date of shipment. View All» UniProt Number: P05112 View All» Entrez Gene Number:

• NM_000589.2

• NM_172348.1
  View All» Gene Symbol:
  • IL4

  • MGC79402

  • Binetrakin

  • Pitrakinra

  • BSF1

  • BSF-1

  • IL-4
    View All» Alternate Names: Interleukin-4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Dot Blot

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P05112 # Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.SIZE: 153 amino acids; 17492 Da SUBCELLULAR LOCATION: Secreted.DISEASE: SwissProt: P05112 # Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.SIMILARITY: SwissProt: P05112 ## Belongs to the IL-4/IL-13 family. View All» Brand Family: Chemicon View All» Product Name: Anti-IL-4 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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