金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:ELISA Development Kit Assay Length:4 hours 40 minutes (after plate preparation) Sample Type & Volume Required:100 µL Sufficient Materials:For fifteen 96-well plates* Range:93.8 - 6,000 pg/mL Specificity:Please see the product datasheet Molecule Information: EDA/Ectodysplasin Aliases: Tabby; XHED; XLHED Entrez Gene IDs: 1896 (Human); 13607 (Mouse) Background: Ectodysplasin (EDA) Ectodysplasin (EDA) is a type II transmembrane protein belonging to the TNF superfamily. It can be expressed as eight alternatively spliced isoforms that are encoded by the EDA gene. Isoforms of EDA are expressed in cells of ectodermal origin, where they are localized to the cell surface and can be released in a soluble form following cleavage by Furin. The EDA-A1 and EDA-A2 splice variants differ by the deletion of two amino acids in the extracellular domain of EDA-A2. Despite this minor difference, EDA-A1 and EDA-A2 display strong receptor specificity. EDA-A1 binds to EDAR, whereas EDA-A2 binds to XEDAR. EDA-A1 and EDA-A2 are required during development, and loss or mutation of EDA results in abnormal development of hair follicles, sweat glands, and teeth. Mutations in the EDA gene are associated with a group of developmental disorders identified as ectodermal dysplasia type 1.