货号：AB1278

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytochrome P450 Enzyme CYP3A4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Binds specifically to cytochrome P450 CYP3A4 in human hepatic microsomal fraction. View All» Immunogen: Synthetic peptide View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1,000 Optimal working dilutions must be determined by end user. View All» Presentation: Sheep antiserum. Liquid, no preservatives. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P08684 View All» Entrez Gene Number: NM_017460.3 View All» Gene Symbol:

• CYP3A4

• CYPIIIA3

• P450-PCN1

• P450C3

• P450PCN1

• MGC126680

• HLp

• CYP3A

• CP34

• CYPIIIA4

• CP33

• NF-25

• HLP

• CYP3A3

• EC 1.14.13.67

• EC 1.14.13.97
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. View All» UniProt Summary: FUNCTION: SwissProt: P08684 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.SIZE: 503 amino acids; 57343 Da SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.TISSUE SPECIFICITY: Expressed in prostate and liver.SIMILARITY: SwissProt: P08684 ## Belongs to the cytochrome P450 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Cytochrome P450 Enzyme CYP3A4 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Sheep View All»
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