货号：AB1427

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin-8 Antibody | AB1427 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human IL-8. No reactivity to IL-1alpha, IL-1beta, IL-2, IL-3, IL4, IL-6, IL-7, IL-10, MIP-1alpha, TNFalpha, GM-CSF and IgG WHO standards by EIA. View All» Molecular Weight: 11 kDa View All» Immunogen: Recombinant human IL-8. View All» Isotype: IgG View All» Background Information: Interleukin-8 (IL-8) is a chemokine produced by macrophages, epithelial cells and endothelial cells. IL-8's primary function is to recruit neutrophils to phagocytose the antigen which trigger the antigen pattern toll-like receptors. IL-8 can be secreted by any cells with toll-like receptors which are involved in a body’s innate immune response. Once IL-8 is secreted, it becomes an important mediator of immune reaction and inflammatory response. IL-8’s monomer and homodimer forms are both inducers of CXCR1 and CXCR2. IL-8 is also believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. View All» Species Reactivity: Human View All» Application Notes: Western blot: A 1:1000-1:3000 dilution of anti-interleukin-8 (IL-8) detected recombinant human IL-8.ELISA: A recommended dilution range of 1:100-1:1000 of anti-interleukin-8 (IL-8) was used on recombinant IL-8.Final working dilutions must be determined by end user. View All» Quality Assurance: Routinely evaluated by western blot on recombinant human IL-8. View All» Purification Method: Protein A purfied View All» Presentation: Liquid in PBS, no preservatives. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: P10145 View All» Entrez Gene Number: NM_000584.2 View All» Gene Symbol:

• IL8

• GCP-1

• emoctakin

• MDNCF

• NAP1

• CXCL8

• AMCF-I

• IL-8

• Emoctakin

• TSG-1

• NAP-1

• LYNAP

• MONAP

• SCYB8

• GCP1

• LUCT

• LECT

• K60

• 3-10C

• b-ENAP

• NAF
  View All» Alternate Names: IL-8 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. View All» UniProt Summary: FUNCTION: SwissProt: P10145 # IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.SIZE: 99 amino acids; 11098 Da SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Secreted.PTM: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.SIMILARITY: SwissProt: P10145 ## Belongs to the intercrine alpha (chemokine CxC) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Interleukin-8 Antibody | AB1427 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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