货号：AB144P

品牌：Merck Millipore

规格：500UL

目录价：￥7355.00

市场价格：￥6251.75

会员价格：￥5884.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Choline Acetyltransferase Antibody | AB144P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. View All» Specificity: Choline acetyltransferase found in cholinergic neurons in brain and spinal cord. View All» Molecular Weight: 70/74 kDa View All» Immunogen: Human placental enzyme. View All» Background Information: Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-choline acetyltransferase a useful specific marker. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Monkey

• Opossum

• Avian

• Chicken

• Guinea Pig

• Zebrafish
  View All» Species Reactivity Note: Human and mouse. Expected to cross-react with Avian, chicken, guinea pig, monkey, rat, and opposum.Demonstrated to react in zebrafish in THE JOURNAL OF COMPARATIVE NEUROLOGY 474:75–107 (2004). View All» Application Notes: Immunohistochemistry: A previous lot of this antibody was used at 1:100. Optimal working dilutions and protocols must be determined by end user. View All» Control: Human placenta lysates, rat forebrain/rostral hypothalamus. View All» Quality Assurance: Routinely evaluated by Western Blot on mouse brain lysates.Western Blot Analysis: 1:1000 dilution of this lot detected CHAT on 10 μg of mouse brain lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified goat polyclonal in buffer containing 5 mg/mL BSA and 0.2% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt. Avoid repeated freeze/thaw cycles. For short term storage (3-4 weeks) maintain at 2-8°C. View All» UniProt Number: P28329 View All» Entrez Gene Number: NM_020549.3 View All» Gene Symbol:
  • CHAT

  • ChAT

  • CHOACTase

  • CMS1A

  • CMS1A2
    View All» Alternate Names:
    • Choline acetylase

    • acetyl CoA:choline O-acetyltransferase

    • choline acetyltransferase

    • ChAT
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Immunocytochemistry

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein. View All» UniProt Summary: FUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.SIZE: 748 amino acids; 82568 Da DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Choline Acetyltransferase Antibody | AB144P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 µL View All» Target / Localization: Cytoplasmic View All» Format: Affinity Purified View All» Host: Goat View All»
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