货号：AB1488P

品牌：Merck Millipore

规格：

目录价：￥3264.00

市场价格：￥2774.40

会员价格：￥2611.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Platelet Factor 4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human PF-4; BLAST analysis of the human immunogen reveals that Sheep PF-4 has 70% identity, Rat PF-4 shows 75% identity, and Pig 71% identity. Cross reactivity with other non-PF-4 related proteins, and other members of the CXCL# family are untested. View All» Immunogen: Highly pure (>98%) recombinant human PF-4 View All» Species Reactivity: Human View All» Application Notes: ELISA: 0.5 μg/mL this dilution will allow detection (in direct ELISA) of 0.2-0.4 ng/well when hPF-4 is used to coat the plate. Western blot: 0.1-0.2 μg/mL, this dilution should offer a detection limit of 1.5-3.0 ng/lane, under reducing or non-reducing conditions. Neutralization: to yield ½ maiximal inhibition (ND50) of the biological activity of hPF-4 (50 ng/mL), a concentration of 1.75-3.0 μg/mL of antibody is required. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from 0.5X PBS pH 7.4. Reconstitute with sterile distilled water. View All» Storage Conditions: The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile water to a concentration of > 0.2 mg/ml the antibody is stable for at least six weeks at 2-4ºC. View All» UniProt Number: P02776 View All» Entrez Gene Number: NM_002619.1 View All» Gene Symbol:

• PF4

• SCYB4

• Iroplact

• PF-4

• CXCL4

• MGC138298
  View All» Alternate Names: PF4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Neutralizing
    View All» Entrez Gene Summary: Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990 [PubMed 1695112]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P02776 # Platelet factor 4, non-covalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes.SIZE: 101 amino acids; 10845 Da SUBUNIT: Homotetramer.SUBCELLULAR LOCATION: Secreted.SIMILARITY: SwissProt: P02776 ## Belongs to the intercrine alpha (chemokine CxC) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Platelet Factor 4 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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