货号：AB1492P

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin-10 Antibody | AB1492P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with mouse IL-10. View All» Immunogen: Highly pure (>98%) recombinant mouse IL-10. View All» Species Reactivity: Mouse View All» Application Notes: Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of mIL-10 (1.0 ng/ml), a concentration of 0.020 - 0.040 μg/ml of AB1492P is required. ELISA: A concentration of at least 0.5μg/ml (100μL/well) of AB1492P is required to detect 0.2 - 0.4 ng/well of recombinant mIL-10. Western Blot: A concentration of 0.1 - 0.2 μg/ml of AB1492P is required to detect 1.5 - 3.0 ng/lane of mIL-10, under either reducing or non-reducing conditions. Optimal working dilutions must be determined by the end user. View All» Presentation: Immunoglobulin purified by affinity chromatography employing immobilized mIL-10 matrix. A sterile filtered antibody solution (1mg/ml) was lyophilized from 0.5X PBS, pH 7.4. Reconstitute with sterile distilled water. View All» Storage Conditions: The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile water to a concentration of >= 0.2 mg/ml the antibody is stable for at least six weeks at 2-4°C. View All» UniProt Number: P22301 View All» Entrez Gene Number: NM_000572.2 View All» Gene Symbol:

• IL10

• CSIF

• IL10A

• MGC126451

• IL-10

• TGIF

• MGC126450
  View All» Alternate Names: IL-10 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Neutralizing
    View All» Entrez Gene Summary: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. View All» UniProt Summary: FUNCTION: SwissProt: P22301 # Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.SIZE: 178 amino acids; 20517 Da SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.DISEASE: SwissProt: P22301 # Defects in IL10 are a cause of susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn disease is commonly classified as autoimmune disease.SIMILARITY: SwissProt: P22301 ## Belongs to the IL-10 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Interleukin-10 Antibody | AB1492P View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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