货号：AB15115

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: NARC-1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Neural apoptosis-regulated convertase 1 [NARC-1, Pcsk9]. By Western blot the antibody recognizes a doublet at ~76 kDa in mouse liver lysate. View All» Immunogen: Synthetic peptide. View All» Species Reactivity: Mouse View All» Purification Method: Serum View All» Presentation: Rabbit serum. View All» Storage Conditions: Maintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q8NBP7 View All» Entrez Gene Number: NM_174936.2 View All» Gene Symbol:

• PCSK9

• NARC1

• NARC-1

• FH3

• HCHOLA3
  View All» Alternate Names: Neural Apoptosis-Regulated Convertase 1, PCSK9 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). View All» UniProt Summary: FUNCTION: SwissProt: Q8NBP7 # May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.COFACTOR: Calcium (Probable).SIZE: 692 amino acids; 74372 Da SUBUNIT: The precursor protein but not the mature protein may form multimers.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.DISEASE:SwissProt: Q8NBP7 # Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.SIMILARITY: SwissProt: Q8NBP7 ## Belongs to the peptidase S8 family. & Contains 1 peptidase S8 domain. View All» Brand Family: Chemicon View All» Product Name: NARC-1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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