金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:ELISA Development Kit for phosphorylated intracellular proteins Assay Length:4 hours 40 minutes (after plate preparation) Sample Type & Volume Required:Cell lysates (100 µL) Sufficient Materials:Kits available for two, five, or fifteen 96-well plates* Range:3.12 - 200 pg/mL Specificity:Please see the product datasheet Molecule Information: ATM Long Name: Ataxia Telangiectasia-mutated Aliases: TEL1; TELO1; TPLL Entrez Gene IDs: 472 (Human); 11920 (Mouse) Background: ATM Germline mutations in the Ataxia Telangiectasia-mutated (ATM) gene lead to the multi-symptom disorder A-T (Ataxia Telangiectasia). Immunodeficiency, neurodegeneration, premature aging, sensitivity to ionizing radiation, and a predisposition to certain types of cancer characterize A-T. The protein product of the gene mutated in A-T is a large protein kinase involved in cell cycle checkpoint and genotoxic stress responses. The ATM protein kinase exists as a dimer in the cell nucleus. Changes in DNA structure induced by genotoxic stress lead to activation of ATM and phosphorylation of S1981 in trans. Once S1981 is phosphorylated, the dimer dissociates and active ATM monomers signal to downstream targets.