货号：AB15192

品牌：Merck Millipore

规格：EA

目录价：￥3550.00

市场价格：￥3017.50

会员价格：￥2840.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Optineurin Antibody | AB15192 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Optineurin. By Western blot the antibody recognizes a band at ~67 kDa on mouse retina lysate. View All» Molecular Weight: 67 kDa View All» Immunogen: Synthetic peptide. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1:500-1:1,000 on mouse retina lysate. Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 &u;L or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. View All» UniProt Number: Q96CV9 View All» Entrez Gene Number:

• NM_001008211.1

• NM_001008212.1

• NM_001008213.1

• NM_021980.4
  View All» Gene Symbol:
  • OPTN

  • FIP-2

  • FIP2

  • HIP7

  • HYPL

  • optineurin

  • Optineurin

  • NRP

  • TFIIIA-INTP

  • GLC1E
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. View All» UniProt Summary: FUNCTION: SwissProt: Q96CV9 # Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.SIZE: 577 amino acids; 65922 Da SUBUNIT: Interacts with E3 14.7 kDa protein of group C human adenovirus. Interacts with HD. Interacts with Rab8 (RAB8A and/or RAB8B). Interacts with transcription factor IIIA (GTF3A).SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Golgi apparatus. Note=Found in the perinuclear region and associates with the Golgi apparatus.TISSUE SPECIFICITY: Present in acqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.PTM: Phosphorylated. Phosphorylation is induced by phorbol esters and decreases its half-time.DISEASE: SwissProt: Q96CV9 # Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E) [MIM:137760]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. & Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG) [MIM:606657]. View All» Brand Family: Chemicon View All» Product Name: Anti-Optineurin Antibody | AB15192 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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