货号：AB152

品牌：Merck Millipore

规格：100UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tyrosine Hydroxylase Antibody | AB152 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Tyrosine hydroxylase. By western blot, AB152 selective labels a single band at approximately 62kDa (reduced) corresponding to Tyrosine Hydroxylase. It is expected that the antibody will react with most mammalian and many non-mammalian species. It has been reported that this antibody does not work on paraffin embedded human tissue. View All» Molecular Weight: 62 kDa View All» Immunogen: Denatured tyrosine hydroxylase from rat pheochromocytoma (denatured by sodium dodecyl sulfate). View All» Background Information: Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Feline

• Ferret

• Squid

• Drosophila

• Mollusk
  View All» Species Reactivity Note: Rat, mouse, ferret, feline, Aplysia (marine mollusc). It is expected that the antibody will react with most mammalian and many non-mammalian species. It has been reported that this antibody does not work on paraffin embedded human tissue. View All» Application Notes: Immunohistochemistry: A previous lot of this antibody was uesd at 1:100-1:1,000 dilution, 4°C, for 1-3 days. Stains both fresh frozen and paraffin embedded tissue samples by indirect immunofluorescence and immunoperoxidase.Immunofluorescence: A previous lot of this antibody was used at 1:100-1:1,000 dilution.Immunoprecipitation: A previous lot of this antibody was used on Immunoprecipitation.ELISA: A previous lot of this antibody was used in ELISA.Optimal dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: Brain (corpus striatum, sympathetic nerve terminals) and adrenal glands.NEGATATIVE CONTROL: Liver. View All» Quality Assurance: Routinely evaluated by Western Blot on PC12 lysates.Western Blot Analysis: 1:1000 dilution of this lot detected tyrosine hydroxylase on 10 μg of PC12 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl (pH 7.5), 100 ug/mL BSA and 50% glycerol. View All» Storage Conditions: Maintain frozen at -20ºC to -70ºC in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer. View All» UniProt Number: P04177 View All» Entrez Gene Number: NM_012740.3 View All» Gene Symbol:
  • TH

  • TYH

  • EC 1.14.16.2
    View All» Alternate Names:
    • Tyrosine 3-hydroxylase

    • Tyrosine 3-hydroxylase

    • tyrosine hydroxylase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunofluorescence

      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. View All» UniProt Summary: FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.COFACTOR: Fe(2+) ion.SIZE: 528 amino acids; 58524 Da TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Tyrosine Hydroxylase Antibody | AB152 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Cytoplasmic View All» Format: Affinity Purified View All» Host: Rabbit View All»
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