货号：AB15242

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-zDHHC8 Antibody | AB15242 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. AB15242 recognizes the C-terminus of zDHHC8. View All» Molecular Weight: ~71 kDa View All» Epitope: C-Terminus View All» Immunogen: Syntheic linear peptide. View All» Background Information: Six genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome–Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode mitochondrial proteins. All six genes are expressed in thebrain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1). View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human and Rat. Predicted to react with horse, pig, opposum, mouse, cow, xenopus, chimp ,chicken, dog, ape. View All» Control: Fetal human brain View All» Quality Assurance: Routinely evaluated by western blot in fetal human brain lysate. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified in PBS with 0.05% NaN3 View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution. View All» UniProt Number: Q9ULC8 View All» Entrez Gene Number: Q9ULC8 View All» Gene Symbol:
  • DHHC-8

  • EC 2.3.1.-

  • KIAA1292

  • ZDHHCL1

  • ZNF378
    View All» Alternate Names:
    • Zinc finger DHHC domain-containing protein 8

    • Zinc finger protein 378

    • membrane-associated DHHC8 zinc finger protein

    • zinc finger, DHHC domain containing 8

    • zinc finger, DHHC domain like containing 1

    • zinc finger, DHHC-type containing 8
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Putative palmitoyltransferase involved in glutamatergic transmission By similarity.Catalytic activity Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.SUBCELLULAR:Cytoplasmic vesicle membrane; Multi-pass membrane proteinPotential. DOMAIN: The DHHC domain is required for palmitoyltransferase activity By similarity.DISEASE: According to Ref.6 and Ref.7, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to Ref.8, Ref.9 and Ref.10, it is not the case.SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.Contains 1 DHHC-type zinc finger. View All» Product Name: Anti-zDHHC8 Antibody | AB15242 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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