货号：AB15325

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nicotinic Acetylcholine Receptor β2 Antibody | AB15325 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Nicotinic Acetylcholine Receptor β2. View All» Molecular Weight: Approx. 55 kDa View All» Epitope: Extracellular Domain View All» Immunogen: This antibody is generated from rabbits immunized with a KLH-conjugated linear peptide selected from residues of Nicotinic Acetylcholine Receptor β2. View All» Modifications: Acetylation View All» Background Information: Nicotinic acetylcholine receptors, also known as nAChRs, belong to a family of proteins called ligand gated ion channels and are widely expressed throughout the nervous system. nAChRs are made up of 5 subunits (two α and three β). Subunits α4 and β2 (α4β2) is the main receptor in the mammalian brain and has been associated with the positive reinforcing effects of nicotine. The relative contribution of nAChRs β2 and β4 are not well understood because the subunit structure that mediates synaptic transmission in the peripheral nervous system is unknown. View All» Species Reactivity:

• Mouse

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Control: Rat e16 brain lysate View All» Quality Assurance: Routinely evaluated by Western Blot in rat e16 brain lysate.Western Blot Analysis: : 1:20,000 dilution of this lot detected Nicotinic Acetylcholine Receptor β2 on 10 µg of rat e16 brain lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 12 months. View All» UniProt Number: P17787 View All» Entrez Gene Number: NP_062170 View All» Gene Symbol:
  • EFNL3

  • OTTHUMP00000035374

  • nAChRB2
    View All» Alternate Names:
    • cholinergic receptor, nicotinic, beta 2 (neuronal)

    • cholinergic receptor, nicotinic, beta polypeptide 2(neuronal)

    • neuronal nicotinic acetylcholine receptor beta 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Co-assembles with the alpha 7 subunit to form a functional heteromeric nicotinic acetylcholine receptor [RGD]. View All» UniProt Summary: FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.SUBUNIT STRUCTURE: Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. INVOLVEMENT IN DISEASE: Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3) [MIM:605375]. ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. SEQUENCE SIMILARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification] View All» Product Name: Anti-Nicotinic Acetylcholine Receptor β2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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