货号：AB15358

品牌：Merck Millipore

规格：EA

目录价：￥3588.00

市场价格：￥3049.80

会员价格：￥2870.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dynamin 1 Antibody | AB15358 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Dynamin 1 (765-778). View All» Molecular Weight: ~100 kDa View All» Epitope: Internal Domain View All» Immunogen: Linear peptide corresponding to amino acids 765-778 of Dynamin 1 conjugated to Dip. Tox. View All» Background Information: Dynamin 1, also known as DNM1, is a human gene. This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. View All» Species Reactivity:

• Rat

• Mouse

• Human

• Canine
  View All» Species Reactivity Note: Human, Mouse, Rat. Predicted to react with dog based on sequence homology. View All» Control: Rat Brain Cytosol Lysate. View All» Quality Assurance: Routinely evaluated by Western Blot on Rat Brain Cytosol Lysate.Western Blot Analysis: 1:5,000 of this lot detected Dynamin 1 on 10 µg of Rat Brain Cytosol Lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Sheep polyclonal serum in buffer containing 0.1M Tris-Glycine (pH7.4) 15mM NaCl containing 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q05193 View All» Entrez Gene Number: NP_001005336.1 View All» Gene Symbol:
  • DNM

  • EC 3.6.5.5
    View All» Alternate Names: dynamin 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq].Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (2), also known as internal form 2 and the short C-terminal form, is shorter and has a distinct C-terminus, compared to isoform 1. View All» UniProt Summary: FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.Catalytic activity GTP + H(2)O = GDP + phosphate.SUBUNIT STRUCTURE:Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 By similarity.SUBCELLULAR LOCATION:Cytoplasm. Cytoplasm › cytoskeleton. Note= Microtubule-associated.SEQUENCE SIMILARITY: Belongs to the dynamin family.Contains 1 GED domain.Contains 1 PH domain. View All» Product Name: Anti-Dynamin 1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Sheep View All»
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