货号：AB15392

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Zic2 Antibody | AB15392 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Zic2. View All» Molecular Weight: 55 kDa View All» Epitope: This antibody recognizes Zic2 at the N-terminus region. View All» Immunogen: This antibody is generated from rabbits immunized with a GST-tagged recombinant protein corresponding to residues in the N-terminus of mouse Zic2. View All» Background Information: Zinc-finger transcription factor (Zic2) is a conserved signaling protein with critical roles in neural development including neurulation, anteroposterior patterning, neural crest formation, cerebellar development, and ipsilateral axonal targeting across the optic chiasm. It activates the transcription of target genes by DNA binding and recruitment of RNA helicase A (RHA). Zic2 has been shown to operate as a transcriptional repressor of cellular proliferation and neurogenesis. Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with markers of neurogenesis. The Zic2kd/kd mice show holoprosencephaly and spina bifida, which derive from malformations in the anterior and posterior ends of the neural tube, respectively. Due to its apparent role in the regulation of granule cell expansion, Zic2 expression is a useful marker for mature granule neurons in the developing cerebellum. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Predicted to react with human, rat, monkey, and cow based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:200 dilution from a previous lot detected Zic2 on mouse cerebellum and hippocampus tissue. View All» Control: Mouse cerebellum lysate View All» Quality Assurance: Evaluated by Western Blot in mouse cerebellum lysate.Western Blot Analysis: : 0.1 µg/ml of this antibody detected Zic2 on 10 µg of mouse cerebellum lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q62520 View All» Entrez Gene Number: NP_033600 View All» Gene Symbol:

• Zic2

• HPE5
  View All» Alternate Names:
  • Zic family member 2 (odd-paired Drosophila homolog)

  • Zic family member 2 (odd-paired homolog, Drosophila)

  • Zinc finger protein of the cerebellum 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Involved in cerebellar development.SUBCELLULAR LOCATION Nucleus. TISSUE SPECIFICITY: CNS. A high level expression is seen in the cerebellum.SEQUENCE SIMILARITIES: Belongs to the GLI C2H2-type zinc-finger protein family.Contains 5 C2H2-type zinc fingers. View All» Product Name: Anti-Zic2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-152181.htm
      © Merck Millipore代理AB15392 Anti-Zic2 Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio