货号：AB1541

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tryptophan Hydroxylase Antibody | AB1541 View All» Replaces: AB1541 is a recommended replacement for AB1556 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Tryptophan Hydroxylase. Reacts with human and rat brain tissues by immunoblotting and immunohistochemistry. Based on the relatively high degree of homology of tryptophan hydroxylase, the antibody should cross-react with other mammalian species. Recently studies have indicated that AB1541 can cross react with Tyrosine hydroxylase on western blots, weakly. Cross reactivity in the native state is untested. View All» Molecular Weight: 55 kDa View All» Immunogen: Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE. View All» Background Information: Tryptophan hydroxylase (TPH) is an enzyme involved in the synthesis of the neurotransmitter serotonin. It is responsible for addition of the -OH group (hydroxylation) to the 5 position to form the amino acid 5-hydroxytryptophan (5-HTP), which is the initial and rate-limiting step in the synthesis of the hormone serotonin. It is also the first enzyme in the synthesis of melatonin. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Reacts with human and rat brain tissues by immunoblotting and immunohistochemistry. Based on the relatively high degree of homology of tryptophan hydroxylase, the antibody should cross-react with other mammalian species. View All» Application Notes: Immunohistochemistry(peroxidase): Performed on formaldehyde fixed tissue of a previous lot. Useful for cell body but not fiber staining.Optimal working dilutions must be determined by the end user. View All» Control:
  • Brain tissue

  • PC12 lysates
    View All» Quality Assurance: Routinely evaluated by Western Blot on PC12 lysates.Western Blot Analysis: 1:1000 dilution of this lot detected Tryptophan Hydroxylase on 10 μg of PC12 lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified sheep polyclonal liquid in 150 mM NaCl, 10 mM HEPES (pH 7.5), 100 μg/mL BSA and 50% glycerol. View All» Storage Conditions: Stable for 6 months at -20ºC to -80ºC in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage. View All» UniProt Number: P17752 View All» Entrez Gene Number: NM_004179.1 View All» Gene Symbol:
    • TPH1

    • TPRH

    • MGC119994

    • TRPH

    • TPH

    • EC 1.14.16.4
      View All» Alternate Names:
      • Tryptophan 5-monooxygenase 1

      • indoleacetic acid-5-hydroxylase

      • tryptophan 5-hydroxylase

      • tryptophan 5-monooxygenase

      • tryptophan hydroxylase (tryptophan 5-monooxygenase)

      • tryptophan hydroxylase 1
        View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
        • Immunohistochemistry

        • Western Blotting
          View All» Entrez Gene Summary: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the gut, pineal gland, spleen, and thymus. View All» UniProt Summary: COFACTOR:Fe(2+) ion.SIZE:444 amino acids; 50985 Da SUBUNIT:Multimer of identical subunits.TISSUE SPECIFICITY:Isoform 2 seems to be less widely expressed than isoform 1.SIMILARITY:SwissProt: P17752 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. & Contains 1 ACT domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Tryptophan Hydroxylase Antibody | AB1541 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Sheep View All»
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