货号：AB15435

品牌：Merck Millipore

规格：EA

目录价：￥3588.00

市场价格：￥3049.80

会员价格：￥2870.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho Stargazin (Ser228) Antibody | AB15435 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Stargazin at the cytoplasmic domain. View All» Molecular Weight: ~ 36 kDa calculated View All» Epitope: Cytoplasmic domain View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Stargazin at the cytoplasmic domain. View All» Background Information: Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival. View All» Species Reactivity:

• Mouse

• Rat

• Human

• Horse

• Opossum
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with rat, human, equine, opossum, marmoset, platypus, and chimpanzee based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A previous lot of this antibody was successfully used by an independent laboratory in WB. (Susumu Tomita, Ph.D., Department of Cellular and Molecular Physiology, Yale University School of Medicine) View All» Control: Modified and non modified peptides of phosphorylated and non-phosphorlyated Stargazin protein View All» Quality Assurance: Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated Stargazin protein.Dot Blot Analysis: 2 µg/mL of this antibody detected Stargazin in modified and non modified peptides of phosphorylated and non-phosphorlyated Stargazin protein. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O88602 View All» Entrez Gene Number: NP_031609 View All» Gene Symbol: stargazin View All» Alternate Names:
  • calcium channel, voltage-dependent, gamma subunit 2

  • Neuronal voltage-gated calcium channel gamma-2 subunit

  • voltage-dependent calcium channel gamma-2 subunit
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Dot Blot
      View All» UniProt Summary: FUNCTION: Thought to stabilize the calcium channel in an inactivated (closed) state.SUBUNIT STRUCTURE: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Brain.PTM: Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.INVOLVEMENT IN DISEASE: Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.SEQUENCE SIMILARITIES: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. View All» Product Name: Anti-phospho Stargazin (Ser228) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-152210.htm
      © Merck Millipore代理AB15435 Anti-phospho Stargazin (Ser228)，产品报价联系微信jinshanbio