货号：AB15454

品牌：Merck Millipore

规格：500UL

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Proteolipid Protein Antibody | AB15454 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: PLP [Proteolipid Protein] View All» Immunogen: Synthetic peptide corresponding to human/mouse PLP protein. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Other species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity. View All» Application Notes: Immunohistochemistry: 1:100-1:200 using 2% paraformaldehyde fixed tissue.Immunocytochemistry: 1:100-1:200 using 2% paraformaldehyde fixed cells.Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS, pH 7.2 with 0.02% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: P60201 View All» Entrez Gene Number:

• NM_000533.3

• NM_199478.1
  View All» Gene Symbol:
  • PLP1

  • lipophilin

  • MMPL

  • PLP/DM20

  • PLP

  • PMD

  • SPG2

  • Lipophilin
    View All» Alternate Names: PLP View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.SIZE: 277 amino acids; 30077 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DISEASE: SwissProt: P60201 # Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia. & Defects in PLP1 are the cause of spastic paraplegia type 2 (SPG2) [MIM:312920]. SPG2 is a form of X-linked hereditary spastic paraplegia (HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Additional features include nystagmus, dysarthria and mental retardation, that are found in the complicated form of spastic paraplegia.SIMILARITY: SwissProt: P60201 ## Belongs to the myelin proteolipid protein family. View All» Brand Family: Chemicon View All» Product Name: Anti-Proteolipid Protein Antibody | AB15454 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Affinity Purified View All» Host: Chicken View All»
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