货号：AB15506

品牌：Merck Millipore

规格：50Ug

目录价：￥5198.00

市场价格：￥4418.30

会员价格：￥4158.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Iron Pegulatory Protein 1 Antibody | AB15506 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Iron regulatory protein 1 (IRP-1). The immunogen sequence has no significant homology with IRP-2. View All» Immunogen: Synthetic peptide near the N-terminus of rat IRP-1. View All» Background Information: Iron regulatory proteins (IRP-1 and IRP-2) are cytoplasmic mRNA-binding proteins that control intracellular iron levels by regulating the translation of ferritin, Tfrs, and other proteins congaing iron-responsive element (IRE) located at the 5'-UTR. IRP binds to IREs with high affinity in situation of iron starvation. Binding of IRP to IRE of ferritin represses its transcription. However, when cells are iron replete, IRPs lose their capacity to bind IREs, allowing efficient translation of ferritin and reducing Tfr mRNA half-life. Although IRP1 and IRP-2 share significant protein sequence homology, they differ in tissue distribution and mode of regulation. IRP-2/IRE-BP2 (rat/human 963 aa) is relatively less abundant than IRP-1 and lacks aconitase activity. It has a unique 73-aa insertion in the N-terminus. In the presence of high iron levels, IRP-2 is rapidly targeted to proteasome-mediated degradation. Although, both IRPs bind the consensus IREs, it is also shown that IRP-2 can recognize an exclusive IRE subset. View All» Species Reactivity: Rat View All» Species Reactivity Note: Other species have not yet been tested. The immunogen sequence is 94% conserved in mouse, and 89% in human and rabbit IRP-1. View All» Application Notes: Western blot: 1-10 µg/mL using ECL. Immunohistochemistry: Not tested. Recommended testing antibody dilution:2-20 µg/mL ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well. Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS with 0.1% BSA. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P21399 View All» Entrez Gene Number: NM_002197.1 View All» Gene Symbol:

• ACO1

• Aconitase

• IREBP

• IRP1

• OTTHUMP00000045233

• IREB1

• EC 4.2.1.3
  View All» Alternate Names: IRP-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. View All» UniProt Summary: FUNCTION: SwissProt: P21399 # This protein also expresses aconitase activity.COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity).SIZE: 889 amino acids; 98399 Da SUBCELLULAR LOCATION: Cytoplasm.SIMILARITY: SwissProt: P21399 ## Belongs to the aconitase/IPM isomerase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Iron Pegulatory Protein 1 Antibody | AB15506 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Rabbit View All»
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