货号：AB15508

品牌：Merck Millipore

规格：50Ug

目录价：￥5018.00

市场价格：￥4265.30

会员价格：￥4014.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Iron Regulatory Protein 2 Antibody | AB15508 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Iron regulatory protein 2 (IRP-2). The immunogen sequence has no significant homology with IRP-1. View All» Immunogen: Synthetic peptide near the N-terminus of human/rat/mouse IRP-2. View All» Background Information: Iron regulatory proteins (IRP-1 and IRP-2) are cytoplasmic mRNA-binding proteins that control intracellular iron levels by regulating the translation of ferritin, Tfrs, and other proteins congaing iron-responsive element (IRE) located at the 5'-UTR. IRP binds to IREs with high affinity in situation of iron starvation. Binding of IRP to IRE of ferritin represses its transcription. However, when cells are iron replete, IRPs lose their capacity to bind IREs, allowing efficient translation of ferritin and reducing Tfr mRNA half-life. Although IRP1 and IRP-2 share significant protein sequence homology, they differ in tissue distribution and mode of regulation. IRP-2/IRE-BP2 (rat/human 963 aa) is relatively less abundant than IRP-1 and lacks aconitase activity. It has a unique 73-aa insertion in the N-terminus. In the presence of high iron levels, IRP-2 is rapidly targeted to proteasome-mediated degradation. Although, both IRPs bind the consensus IREs, it is also shown that IRP-2 can recognize an exclusive IRE subset. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: The immunogen sequence is 100% conserved in human, rat, and mouse IRP-2. View All» Application Notes: Western blot: 1-10 µg/mL using ECL. Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well. Optimal working dilutions must be determined by end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS with 0.1% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P48200 View All» Entrez Gene Number: NM_004136.2 View All» Gene Symbol:
  • IREB2

  • IRP2AD

  • FLJ23381

  • IRP2

  • ACO3
    View All» Alternate Names: IRP-2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P48200 # Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity).SIZE: 963 amino acids; 105012 Da SUBCELLULAR LOCATION: Cytoplasm.SIMILARITY: SwissProt: P48200 ## Belongs to the aconitase/IPM isomerase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Iron Regulatory Protein 2 Antibody | AB15508 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-152257.htm
      © Merck Millipore代理AB15508 Anti-Iron Regulatory Protein 2 Antibody;store at -20℃，产品报价联系微信jinshanbio