货号：AB1552

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nitric Oxide Synthase I Antibody | AB1552 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Western blot analysis of rat cerebellum and cortex shows a strong major band of 155 kDa. AB1552 reacts with NOS-containing (and NADPH-diaphorase positive) neuronal cell bodies throughout the central nervous system of mouse, rat and ferret. Endothelial cells and macrophages within the CNS are unstained using this antibody. The immunostaining is fully abolished by pre-absorption of the antibody with the immunogen peptide. View All» Immunogen: Synthetic peptide corresponding to amino acid residues 1414-1429 of the rat NOS-I protein (Bredt et al., 1991), conjugated to KLH via a maleimido linkage. The peptide is unique to the neuronal isoform of nitric oxide synthase. View All» Species Reactivity:

• Ferret

• Mouse

• Rat
  View All» Application Notes: Immunocytochemistry: 1:500-1:1,000 (Can be used successfully on paraformaldehyde-fixed cryostat or vibratome sections.). Western blot: 1:500-1:1,000. Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Purified by caprylic acid and ammonium sulfate precipitation. Liquid in PBS containing 0.1% BSA and 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated thawing and refreezing. View All» UniProt Number: P29475 View All» Entrez Gene Number: NM_000620.1 View All» Gene Symbol:
  • NOS1

  • nNOS

  • NC-NOS

  • N-NOS

  • IHPS1

  • bNOS

  • NOS

  • EC 1.14.13.39
    View All» Alternate Names: NOS I; bNOS; nNOS View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: SwissProt: P29475 # Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.COFACTOR: Heme group. & Binds 1 FAD. & Binds 1 FMN. & Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.SIZE: 1434 amino acids; 160970 Da SUBUNIT: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity).SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.DOMAIN: SwissProt: P29475 The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles (By similarity).DISEASE: SwissProt: P29475 # Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction.SIMILARITY: Belongs to the NOS family. & Contains 1 flavodoxin-like domain. & Contains 1 PDZ (DHR) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Nitric Oxide Synthase I Antibody | AB1552 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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