货号：AB15552-200UL

品牌：Merck Millipore

规格：200UL

目录价：￥10062.00

市场价格：￥8552.70

会员价格：￥8049.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AT1 Receptor Antibody | AB15552-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes AT1 Receptor (Angiotensin II receptory type 1, AGTR1). View All» Immunogen: Purified peptide from the N-terminus of human AT1 Receptor (Accession number P30556). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:200-1:500 using ECL on rat liver, rat kidney, mouse heart and mouse kidney lysate. Immunohistochemistry on rat brain sections. Immunocytochemistry: 1:100 Flow cytometry, indirect: 5-10 µg of antibody /1 x 106 cells Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Control: Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 µL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P30556 View All» Entrez Gene Number:
  • NM_000685.4

  • NM_004835.3

  • NM_009585.3

  • NM_031850.2

  • NM_032049.2
    View All» Gene Symbol:
    • AGTR1

    • AT2R1A

    • AT2R1B

    • AGTR1B

    • AT2R1

    • AT1BR

    • AGTR1A

    • AT1AR

    • AG2S

    • HAT1R

    • AT1

    • AT1B
      View All» Alternate Names: Angiotensin II receptory type 1, AGTR1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Immunocytochemistry

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least four transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. View All» UniProt Summary: FUNCTION: SwissProt: P30556 # Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.SIZE: 359 amino acids; 41061 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Liver, lung, adrenal and adrenocortical adenomas.PTM: C-terminal Ser or Thr residues may be phosphorylated.DISEASE: SwissProt: P30556 # Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).SIMILARITY: SwissProt: P30556 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-AT1 Receptor Antibody | AB15552-200UL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Rabbit View All»
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