货号：AB1555P

品牌：Merck Millipore

规格：10Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NMDAR2A Antibody | AB1555P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: NMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes. Does not react with NMDAR2B or NMDAR2C. Immunolabeling is blocked by preadsorption of antibody with the immunogen. View All» Molecular Weight: 180 kDa View All» Epitope: C-terminus View All» Immunogen: C-Terminal Fusion Protein of rat NMDAR2A, aa 1253-1391. View All» Background Information: NMDA (N-methyl-D-aspartate) receptors are a class of ionotropic glutamate receptors. The NMDAR channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). View All» Species Reactivity:

• Human

• Mouse

• Rat

• Fish
  View All» Species Reactivity Note: Human, rat, mouse, and fish. View All» Application Notes: Immunoprecipitation: 3 μg of a previous lot was used to (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200 μg of rat brain.Immunohistochemistry: A previous lot of this antibody was used at 1:1,000-1:2,000 dilution.Optimal working dilutions must be determined by the end user. View All» Control: NMDAR2A is present in high concentrations in the hippocampus. View All» Quality Assurance: Routinely evaluated by Western Blot on Rat Brain Microsomal lysates.Western Blot Analysis: 1:500 dilution of this lot detected NMDAR2A on 10 μg of Rat Brain Microsomal lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservative. View All» Storage Conditions: Lyophilized material stable for 1 year at -20°C from date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up 6 months. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q12879 View All» Entrez Gene Number: NP_000824 View All» Gene Symbol:
  • GRIN2A

  • hNR2A

  • Glutamate

  • NMDAR2A

  • NR2A
    View All» Alternate Names:
    • N-methyl D-aspartate receptor subtype 2A

    • N-methyl-D-aspartate receptor subunit 2A

    • NMDA receptor subtype 2A

    • glutamate receptor, ionotropic, N-methyl D-aspartate 2A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] View All» UniProt Summary: Function: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.Subunit structure: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 By similarity.Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Sequence similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification] View All» Brand Family: Chemicon View All» Product Name: Anti-NMDAR2A Antibody | AB1555P View All» Concentration: 0.2 mg/mL after reconstitution with 50 μL PBS. View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 10 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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