货号：AB15562-200UL

品牌：Merck Millipore

规格：200UL

目录价：￥10062.00

市场价格：￥8552.70

会员价格：￥8049.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Transient Receptor Potential Channel 7 Antibody | AB15562-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Transient Receptor Potential Channel 7 (TRPM7, LTRPC7, Channel-kinase 1). View All» Immunogen: Purified peptide from the C-terminus of human TRPM7 (Accession number Q96QT4). View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:200-1:500 using ECL on mouse brain lysate and GH3 cell line (rat pituitary tumor) lysate. Immunocytochemistry: 1:200 using GH3 cell line (rat pituitary tumor). Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Control: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 uL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q96QT4 View All» Entrez Gene Number: NM_017672.3 View All» Gene Symbol:
  • TRPM7

  • TRP-PLIK

  • LTRPC7

  • LTrpC7

  • FLJ20117

  • CHAK

  • FLJ25718

  • CHAK1

  • EC 2.7.11.1
    View All» Alternate Names: TRPM7, LTRPC7, Channel-kinase 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q96QT4 # Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).COFACTOR: Binds 1 zinc ion per subunit (By similarity).SIZE: 1865 amino acids; 212697 Da SUBUNIT: Homodimer (By similarity). Forms heterodimers with TRPM6.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).PTM: Autophosphorylated (By similarity).DISEASE: SwissProt: Q96QT4 # Defects in TRPM7 influences susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 [MIM:105500]; also called amyotrophic lateral sclerosis- parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodengenerative disorder with unusually high incidence among the Chamorro people of the Western Pacific Islands of Guam. Both amyotrophic lateral sclerosis and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.SIMILARITY: SwissProt: Q96QT4 ## In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. & Contains 1 alpha-type protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Transient Receptor Potential Channel 7 Antibody | AB15562-200UL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-152310.htm
      © Merck Millipore代理AB15562-200UL Anti-Transient Receptor Potential Channel 7 Antibody;store at -20℃，产品报价联系微信jinshanbio