货号：AB15642

品牌：Merck Millipore

规格：

目录价：￥4551.00

市场价格：￥3868.35

会员价格：￥3640.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Hey L/HRT3 Antibody | AB15642 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB15642 recognizes Hey L at N-Terminus. View All» Molecular Weight: ~35 kDa View All» Epitope: N-Terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the region around the N-Terminus. View All» Background Information: The basic helix-loop-helix class of transcription factors consists of several families of eukaryotic transcriptional activators involved ingeneral, tissue specific, and developmental gene regulation including the ASH, HES, NeuroD, and Neurogenin families, among others. Family members are characterized by the possession of a structurally conserved DNA binding and dimerization motif referred to as the basic helix-loop-helix (bHLH). The bHLH motif is composed of two distinct domains. The helix-loop-helix domain is composed of two amphipathic α-helices linked by amino acid sequences of variable length (the “loop”). For review see: Murre, C. and Baltimore, D. (1992). Lab. Press, p. 861-879. HeyL is a human gene which stands for Hairy/enhancer-of-split related with YRPW motif-like. HeyL is part of a group of basic helix-loop-helix (bhlh) proteins that are transcription factors. Diseases associated with this protein are cardiovascular disease. View All» Species Reactivity: Rat View All» Species Reactivity Note: Rat. Does not react with human and mouse. Predicted to react with cow; horse, chimp, and rhesus based on homology. View All» Control: Rat Testis tissue lysate View All» Quality Assurance: Routinely evaluated by Western Blot on rat testis tissue lysate.Western Blotting Analysis: 1:500-1:2,000 dilution of this lot was used to detect Hey L/HRT3 in rat testis tissue lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Purified antibody in PBS with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q9NQ87 View All» Entrez Gene Number: NP_055386 View All» Gene Symbol:

• HRT3

• MGC12623

• OTTHUMP00000000536

• hHRT3

• hHeyL
  View All» Alternate Names:
  • HEY-like protein

  • Hairy-related transcription factor 3

  • hairy/enhancer-of-split related with YRPW motif-like
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development By similarity. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' By similarity. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.SUBUNIT STRUCTURE: Self-associates By similarity. Interacts with GATA4, GATA6, HES1, HEY1 and HEY2 By similarity. Interacts with HDAC1, NCOR1 and SIN3A By similarity.SUBCELLULAR LOCATION:NucleusBy similarity. IINDUCTION: By activation of the Notch signaling pathway. Ref.5SEQUENCE SIMILARITIES: Belongs to the HEY family.Contains 1 basic helix-loop-helix (bHLH) domain.Contains 1 Orange domain. View All» Product Name: Anti-Hey L/HRT3 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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