货号：AB15728

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuronal Calcium Sensor 1 Antibody | AB15728 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: AB15728 recognizes rat neuronal calcium sensor-1 View All» Molecular Weight: ~21 kDa View All» Immunogen: HPLC purified, myristoylated full-length recombinant rat neuronal calcium sensor-1 produced in E. coli View All» Background Information: Neuronal calcium sensor is a regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. It directly regulates GRK1, but not GRK2 to GRK5. Neuronal calcium sensor-1 (NCS-1), as a calcium binding protein, plays an important role in the modulation of neurotransmitter release and phosphatidylinositol signaling pathway. It is known that the physiological activity of NCS-1 is governed by its myristoylation and it has been suggested that myristoylation influences the protein conformation and calcium binding, which may be crucial for its physiological function, (Jeromin, et al, 2004). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. Reactivity with other species has not been tested. View All» Application Notes: Immunohistochemistry Analysis:Immunoreactivity on the CA1 area of mouse hippocampus using anti-NCS-1, AB15728. Animals were perfusion-fixed with a fixative containing 4% paraformaldehyde and 0.1% glutaraldehyde. The 40 μm section was incubated with anti-NCS-1 at a dilution of 1:1000, and visualized with a donkey anti-rabbit IgG antibody conjugated to FITC. The diffuse labeling of NCS-1 is present throughout all layers of the CA1 area. View All» Control: Rat brain lysate View All» Quality Assurance: Routinely evaluated by western blot on rat brain lysate View All» Purification Method: Affinity Purfied View All» Presentation: Affinity purified in PBS containing 0.05% NaN3 View All» Storage Conditions: Maintain at 2-8°C for up to 1 year from date of receipt. View All» UniProt Number: P62166 View All» Entrez Gene Number: NP_001122298.1 View All» Gene Symbol:
  • DKFZp761L1223

  • FLUP

  • NCS-1

  • NCS1

  • OTTHUMP00000022356
    View All» Alternate Names:
    • Frequenin homolog

    • Frequenin-like protein

    • Frequenin-like ubiquitous protein

    • frequenin (Drosophila) homolog

    • frequenin homolog (Drosophila)

    • neuronal calcium sensor 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). SUBUNIT: Interacts with KCND2. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. MISCELLANEOUS: Binds 3 calcium ions via the second, third and fourth EF-hand. SIMILARITY: Belongs to the recoverin family. SIMILARITY: Contains 4 EF-hand domains. View All» Product Name: Anti-Neuronal Calcium Sensor 1 Antibody | AB15728 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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