货号：AB15852

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HTRA1 Serine peptidase Antibody | AB15852 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: HTRA1 Serine peptidase. By Western blot the antibody reacts with a band at ~ 50 kDa on human heart lysate. An additional band at ~240 kDa may also be seen depending on sample and antibody concentration used. View All» Immunogen: Synthetic peptide from human HTRA1 Serine peptidase. View All» Background Information: The defining features of the widely conserved HtrA (high temperature requirement) family of serine proteases are the combination of a catalytic protease domain with one or more C-terminal PDZ domains and reversible zymogen activation. Even though HtrAs have previously been implicated in protein quality control and various diseases, including cancer, arthritis, and neuromuscular disorder, the biology of the human family members is not well understood. New studies suggest that HtrA1 is directly involved in the amyloid pathway as it degrades various fragments of amyloid precursor protein while an HtrA1 inhibitor causes accumulation of amyloid beta in astrocyte cell culture supernatants. Furthermore, HtrA1 colocalizes with amyloid deposits in human brain samples. View All» Species Reactivity: Rat View All» Purification Method: Protein A purfied View All» Presentation: Liquid in PBS with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: Q92743 View All» Entrez Gene Number: NM_002775.3 View All» Gene Symbol:

• HTRA1

• IGFBP5-protease

• HtrA

• HTRA

• PRSS11

• ARMD7

• ORF480

• L56

• EC 3.4.21.-
  View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. View All» UniProt Summary: FUNCTION: SwissProt: Q92743 # Protease that regulate the availability of IGFs by cleaving IGF-binding proteins.SIZE: 480 amino acids; 51287 Da SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Expressed in a variety of tissues, with strongest expression in placenta.DISEASE: SwissProt: Q92743 # Variations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.SIMILARITY: SwissProt: Q92743 ## Belongs to the peptidase S1B family. & Contains 1 IGFBP N-terminal domain. & Contains 1 Kazal-like domain. & Contains 1 PDZ (DHR) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-HTRA1 Serine peptidase Antibody | AB15852 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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