货号：AB15928

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vitamin K dependent protein S Antibody | AB15928 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Vitamin K dependent protein S. View All» Molecular Weight: Approx. 69-75 kDa View All» Immunogen: This antibody is generated from rabbits immunized with a KLH-conjugated linear peptide corresponding to residues surrounding the mature peptide region of Vitamin K dependent protein S. View All» Background Information: Vitamin K dependent protein S is an anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. View All» Species Reactivity:

• Mouse

• Human

• Horse

• Chimpanzee

• Monkey

• Rat

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with human, horse and chimpanzee. Monkey (93%) and Rat (93%) Rhesus Monkey (93%). View All» Application Notes: Immunoprecipitation Analysis: 1:50,000 dilution from a previous lot detected Vitamin K dependent protein S on 15 µg of normal mouse serum. View All» Control: Mouse liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse liver tissue lysate.Western Blot Analysis: : 1:1000 dilution of this antibody detected Vitamin K dependent protein S on 10 µg of mouse liver tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for 1 year from date of receipt. View All» UniProt Number: P07225 View All» Entrez Gene Number: NP_000304.2 View All» Gene Symbol:
  • PROS

  • PS21

  • PS22

  • PS23

  • PS24

  • PS25

  • PSA
    View All» Alternate Names:
    • protein S (alpha)

    • protein S, alpha

    • protein Sa

    • vitamin K-dependent plasma protein S
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. View All» UniProt Summary: FUNCTION: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Plasma.PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.INVOLVEMENT IN DISEASE: Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. SEQUENCE SIMILARITIES: Contains 4 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 2 laminin G-like domains.SEQUENCE CAUTION: The sequence AAP45054.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti- Vitamin K dependent protein S View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-152514.htm
      © Merck Millipore代理AB15928 Anti-Vitamin K dependent protein S Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio