货号：AB1625

品牌：Merck Millipore

规格：

目录价：￥3440.00

市场价格：￥2924.00

会员价格：￥2752.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calpain II Antibody, large (catalytic) subunit | AB1625 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with m-calpain (Calpain II) large subunit. View All» Epitope: large (catalytic) subunit View All» Immunogen: Human placental m-calpain. View All» Species Reactivity: Human View All» Application Notes: Immunoblot: 1:100 ELISA: 1:6,000 (against the immunogen) Immunohistochemistry: 1:100 on 4% paraformaldehyde fixed tissue. Immunocytochemistry. Tested positive on the following human cells: A431 epidermal carcinoma, MDB-MB-134-VI ductal breast carcinoma, C-33A cervical carcinoma, TE2 esophageal carcinoma, HET-1A esophageal carcinoma and normal human monocytes. Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit antiserum absorbed with human m-calpain bound to Sepharose™. Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P17655 View All» Entrez Gene Number: NM_001748.4 View All» Gene Symbol:

• CAPN2

• millimolar-calpain

• M-calpain

• Millimolar-calpain

• mCANP

• FLJ39928

• CANP2

• CANPml

• CANPL2

• EC 3.4.22.53
  View All» Alternate Names: m-Calpain; Calpain 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» Entrez Gene Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P17655 # Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.COFACTOR: Binds 3 calcium ions.SIZE: 700 amino acids; 80009 Da SUBUNIT: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: SwissProt: P17655 ## Belongs to the peptidase C2 family. & Contains 1 calpain catalytic domain. & Contains 3 EF-hand domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Calpain II Antibody, large (catalytic) subunit | AB1625 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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