货号：AB1665

品牌：Merck Millipore

规格：100UL

目录价：￥7049.00

市场价格：￥5991.65

会员价格：￥5639.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fas Ligand Antibody | AB1665 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Immunogen: An 18 amino acid peptide sequence (aa 130-146) from rat FASL. This sequence is known to be 94% homologous with mouse FASL, differing by one amino acid. This peptide region does not show significant homology with human FASL, with only four amin View All» Species Reactivity:

• Mouse

• Rat
  View All» Non-Reactive Species: Human View All» Application Notes: Western blotting:1:1000 - 1:5,000, using Chemiluminescent detection. The use of 0.1 - 0.5% milk in diluents is recommended to reduce background. Based upon the calculated amino acid sequences, rat (278), mouse (279), and human (281) FASL has a molecular weight of ~32 kDa. A 40 kDa FASL band has been detected in mouse T cells. ELISA: 1:10,000 - 1:50,000, for detection of control peptide (AG626) coated at a 1 μg/mL concentration. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid antiserum containing 0.05% sodium merthiolate as a preservative. View All» Storage Conditions: Store at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze-thaw cycles. View All» UniProt Number: P48023 View All» Entrez Gene Number: NM_000639.1 View All» Gene Symbol:
  • FASLG

  • FASL

  • CD95L

  • CD178

  • TNFSF6

  • FasL

  • APT1LG1

  • APTL
    View All» Alternate Names: FasL View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). View All» UniProt Summary: FUNCTION: SwissProt: P48023 # Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.SIZE: 281 amino acids; 31485 Da SUBUNIT: Homotrimer (Probable).SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface.PTM: N-glycosylated. & The soluble form derives from the membrane form by proteolytic processing.DISEASE: SwissProt: P48023 # Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.SIMILARITY: SwissProt: P48023 ## Belongs to the tumor necrosis factor family. View All» Brand Family: Chemicon View All» Product Name: Anti-Fas Ligand Antibody | AB1665 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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