货号：AB1673

品牌：Merck Millipore

规格：100UL

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Leptin Antibody | AB1673 View All» Replaces: AB3385P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with mouse leptin. View All» Immunogen: Recombinant mouse leptin. View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1:1,000 RIA: 1:1,000 Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin in PBS. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in diluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P48357 View All» Entrez Gene Number:

• NM_001003679.1

• NM_001003680.1

• NM_002303.3
  View All» Gene Symbol:
  • LEPR

  • DB

  • OBR

  • CD295

  • OB-R

  • LEP-R

  • HuB219
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Radioimmunoassay

    • Western Blotting
      View All» Entrez Gene Summary: Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P48357 # Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).SIZE: 1165 amino acids; 132494 Da SUBUNIT: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits LRb signaling (By similarity).SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform E: Secreted (Probable).TISSUE SPECIFICITY: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.DOMAIN: SwissProt: P48357 The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs. & The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. & The box 1 motif is required for JAK interaction and/or activation.PTM: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.SIMILARITY: Belongs to the type I cytokine receptor family. Type 2 subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 Ig-like (immunoglobulin-like) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Leptin Antibody | AB1673 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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