货号：AB16921

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DNase II, C-terminus View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of the caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus (Zamzami et al. 1999). DNase II causes both chromatin condensation and DNA fragmentation (Zamzami et al. 1999). The genes encoding human (Yasuda et al. 1998; Krieser et al. 1998; Shiokawa et al. 1998), porcine (Shiokawa et al. 1998), and murine (Baker et al. 1998) DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (a) and 12 kDa (b) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation (Krieser et al. 1998). DNase II is uniquitously expressed in human tissues. View All» Epitope: C-terminus View All» Immunogen: Polyclonal antibody raised against a peptide (C-terminus) corresponding to amino acids 347-360 of human RAIDD (Yasua et al. 1998; Krieser et al. 1998; Shiokawa et al. 1998). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500-1:1000 Tissue lysate of human spleen can be used as a positive control and a 32 kDa (alpha chain) band can be detected. Antibody does not recognize the 12 kDa beta chain. Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: O00115 View All» Entrez Gene Number: NM_001375.2 View All» Gene Symbol:

• DNASE2

• DNASE2A

• DNL

• DNL2

• R31240_2

• EC 3.1.22.1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. View All» UniProt Summary: FUNCTION: SwissProt: O00115 # Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.SIZE: 360 amino acids; 39581 Da SUBCELLULAR LOCATION: Lysosome.PTM: Glycosylated. Mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect.SIMILARITY: SwissProt: O00115 ## Belongs to the DNase II family. MISCELLANEOUS: Not required for the generation of the characteristic DNA fragmentation observed in apoptotic cells, but for the degradation of DNA from dying cells (By similarity). View All» Brand Family: Chemicon View All» Product Name: Anti-DNase II, C-terminus View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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