货号：AB16957

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRAIL Antibody, C-terminus | AB16957 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (Pan et al. 1997; Wiley et al. 1995). TRAIL is a type II membrane protein and is expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL (Pitti et al. 1996; Schneider et al. 1997; Pan et al. 1997). Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells. View All» Epitope: C-terminus View All» Immunogen: Polyclonal antibody raised against a peptide corresponding to amino acids 261-277 of human TRAIL. View All» Background Information: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (1,2). TRAIL is a type II membrane protein and is expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL (3-5). Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500 Whole cell lysate from HeLa cells can be used as a positive control and a 32 kDa band, which represents a membrane bound form of TRAIL, should be detected. Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P50591 View All» Entrez Gene Number: NM_003810.2 View All» Gene Symbol:

• TNFSF10

• TRAIL-PEN

• TL2

• Apo-2L

• CD253

• APO2L

• TRAIL
  View All» Alternate Names: Apo2 Ligand View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. View All» UniProt Summary: FUNCTION: SwissProt: P50591 # Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.COFACTOR: Binds 1 zinc ion per trimer.SIZE: 281 amino acids; 32509 Da SUBUNIT: Homotrimer.SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate.SIMILARITY: SwissProt: P50591 ## Belongs to the tumor necrosis factor family. View All» Brand Family: Chemicon View All» Product Name: Anti-TRAIL Antibody, C-terminus | AB16957 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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