货号：AB16965

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ICAD/DFF Antibody, N-terminus (a.a. 2-21 of mouse ICAD) | AB16965 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated Dnase. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by caspase-3 during apoptosis (Liu et al. 1997). Mouse homologue of human DFF was identified as a Dnase inhibitor designated ICAD (Enari et al. 1998; Sakahira et al. 1998). Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei (Enari et al. 1998; Sakahira et al. 1998). Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which cause Dnase activation and DNA degradation, is the hallmark of apoptotic cell death (Wylile et al. 1998). View All» Epitope: N-terminus (a.a. 2-21 of mouse ICAD) View All» Immunogen: Polyclonal antibody raised against a peptide corresponding to amino acids 2-21 of mouse ICAD (Enari et al. 1998). View All» Species Reactivity: Mouse View All» Application Notes: Western blot: 1:500-1:1000 Mouse lung tissue lysate can be used as a positive control and a 45 kDa band should be detected. Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: O00273 View All» Entrez Gene Number:

• NM_004401.2

• NM_213566.1
  View All» Gene Symbol:
  • DFFA

  • DFF45

  • DFF-45

  • ICAD

  • DFF1
    View All» Alternate Names: Inhibitor of Caspase Activated Deoxyribonuclease; DFF View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: O00273 # Inhibitor of the caspase-activated DNase (DFF40).SIZE: 331 amino acids; 36522 Da SUBUNIT: Heterodimer of DFFA and DFFB.SUBCELLULAR LOCATION: Cytoplasm.PTM: Caspase-3 cleaves DFF45 at 2 sites to generate an active factor. & Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: O00273 ## Contains 1 CIDE-N domain. View All» Brand Family: Chemicon View All» Product Name: Anti-ICAD/DFF Antibody, N-terminus (a.a. 2-21 of mouse ICAD) | AB16965 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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