货号：AB17003

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bim Antibody, internal epitope, pan-Bim isoforms | AB17003 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes pan-Bim isoforms. View All» Molecular Weight: 23 kDa View All» Epitope: internal epitope, pan-Bim isoforms View All» Immunogen: Synthetic peptide corresponding to amino acids 22-40 of human origin (O'Conneor et al. 1998). The sequence is identical to that of mouse and is different by one amino acid from that of rat. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:1000-1:2000 Human K562 cell lysate can be used as a positive control and a 23 kDa band can be detected. Optimal working dilutions must be determined by end user. View All» Control: Skin/Skin Tumor View All» Purification Method: Immunoaffinity purified View All» Presentation: Immunoaffinity Purified immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative. View All» Storage Conditions: The undiluted antibody solution is stable for approximately 6 months when stored 2–8°C. View All» UniProt Number: O43521 View All» Alternate Names: BOD View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: Function: Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis. Subunit structure: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK By similarity.Subcellular location: Endomembrane system; Peripheral membrane protein By similarity. Note: Associated with intracytoplasmic membranes By similarity. Isoform BimEL: MitochondrionIsoform BimL: Mitochondrion Isoform BimS: Mitochondrion Isoform Bim-alpha1: Mitochondrion Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. Ref.3Domain: The BH3 motif is required for Bcl-2 binding and cytotoxicity.Sequence similarities: Belongs to the Bcl-2 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Bim Antibody, internal epitope, pan-Bim isoforms | AB17003 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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