货号：AB1723

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bcl-W Antibody, a.a. 16-29 | AB1723 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This immunoaffinity purified antibody detects a 21 kDa protein, corresponding to the expected molecular mass of Bcl-w, in human fibroblast (A431), human cervical epithelial (HeLa), human tonsil (Hs198), human thymus (Hs67), monkey kidney (vero) and mouse fibroblast (3T3) cell lysates, as well as rat brain, rat testis, mouse brain, mouse testis and bovine brain tissue extracts. An additional weak cross reactivity with an 18 kDa band is observed in some cell lysates. This reactivity may represent binding to Bcl-x, as these proteins are 64% homologous over the region of the peptide immunogen. The antibody specificity is confirmed by peptide inhibition studies. View All» Epitope: a.a. 16-29 View All» Immunogen: Human Bcl-w synthetic peptide (aa. 16-29) with an additional cysteine residue coupled to KLH. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Monkey

• Rat
  View All» Application Notes: Western Blot: 4μg/mL Immunohistochemistry in paraffin embedded sections {Sun, et al 2003} 1:200, 4% PFA fixed tissue. Optimal working dilutions must be determined by the end user. View All» Presentation: Purified Immunoglobulin at 1.7 mg/mL. Liquid in borate buffered saline, pH 8.2 (25mM sodium borate, 100mM boric acid, 75mM NaCl, 5mM EDTA (disodium salt)). No preservatives. View All» Storage Conditions: The undiluted antibody solution is stable for approximately 6 months when stored -20°C. View All» UniProt Number: Q92843 View All» Entrez Gene Number: NM_004050.3 View All» Gene Symbol:
  • BCL2L2

  • KIAA0271

  • BCLW

  • BCL-W
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. View All» UniProt Summary: FUNCTION: SwissProt: Q92843 # Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.SIZE: 193 amino acids; 20774 Da SUBCELLULAR LOCATION: Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.TISSUE SPECIFICITY: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.DOMAIN: SwissProt: Q92843 The BH4 motif seems to be involved in the anti-apoptotic function. & The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3- binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.SIMILARITY: Belongs to the Bcl-2 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Bcl-W Antibody, a.a. 16-29 | AB1723 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Rabbit View All»
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