货号：AB1730

品牌：Merck Millipore

规格：

目录价：￥5657.00

市场价格：￥4808.45

会员价格：￥4525.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bid (full length) Antibody | AB1730 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: AB1730 detects the full length (22 kDa), detection of the 15kDa truncated form is very difficult with AB1730. View All» Immunogen: An 18 amino acid synthetic peptide peptide surrounding amino acid 37 of human Bid (ID# BV63-64), corresponding to a region near the N-terminus of human Bid. View All» Background Information: Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is known to interact with Bcl-2 and Bax. It has been reported that Bid induces cytochrome c release from mitochondria following cleavage by caspase-8 in response to apoptotic stimuli transmitted through cell surface death receptors. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1 μg/mL Immunoprecipitation: 5-10 μg/mL Immunohistochemistry: 20-40 μg/mL Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin in liquid in PBS, pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal. View All» Storage Conditions: Maintain frozen at -20°C for up to 12 momnths from date of receipt. For optimal storage, aliquot and freeze at -20°C to -70°C. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P55957 View All» Entrez Gene Number:
  • NM_001196.2

  • NM_197966.1

  • NM_197967.1
    View All» Gene Symbol:
    • BID

    • FP497

    • MGC42355

    • MGC15319
      View All» Alternate Names: BH3 Interacting Domain Death Agonist View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. View All» UniProt Summary: FUNCTION: SwissProt: P55957 # The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.SIZE: 195 amino acids; 21995 Da SUBUNIT: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Mitochondrion membrane (By similarity). Note=When uncleaved, it is predominantly cytoplasmic. & BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). Note=Translocates to mitochondria as an integral membrane protein (By similarity). & BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Note=Associated with the mitochondrial membrane (By similarity). & Isoform 1: Cytoplasm. & Isoform 3: Cytoplasm. & Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.TISSUE SPECIFICITY: Isoforms 2 and 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).DOMAIN: SwissProt: P55957 Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.PTM: TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: View All» Brand Family: Chemicon View All» Product Name: Anti-Bid (full length) Antibody | AB1730 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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