货号：AB176

品牌：Merck Millipore

规格：EA

目录价：￥3680.00

市场价格：￥3128.00

会员价格：￥2944.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Adenosine Deaminase Antibody | AB176 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Adenosine Deaminase. View All» Immunogen: Calf Spleen Adenosine Deaminase. Due to high sequence identity, the antiserum is expected to react with adenosine deaminase from most mammalian species. View All» Species Reactivity:

• Bovine

• Rat
  View All» Application Notes: Immunohistochemistry - 1:250 (Fixative 4.0% paraformaldehyde). ELISA - 1:3,000. Western Blot - 1:2,500 (41 kDa). Optimal working dilutions must be determined by end user. View All» Presentation: Rabbit antiserum. View All» Storage Conditions: Maintain at -20°C for up to 6 months or -70°C for up to 12 months in undiluted aliquots. View All» UniProt Number: P00813 View All» Entrez Gene Number: NM_000022.2 View All» Gene Symbol:
  • ADA

  • EC 3.5.4.4
    View All» Alternate Names: Adenosine Aminohydrolase; EC 5.4.3.3) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. View All» UniProt Summary: SIZE: 363 amino acids; 40764 Da TISSUE SPECIFICITY: Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.DISEASE: SwissProt: P00813 # Defects in ADA are a cause of autosomal recessive severe combined immuno-deficiency (SCID) [MIM:102700]. SCID is a congenital disorder characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Onset is during infancy. Less often, immune dysfunction develops later in childhood (delayed) and in a few cases ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Population and newborn screening programs have also identified several healthy individuals with normal immunity, mainly in African descent, who have partial ADA deficiency. Most patients are compound heterozygotes. SCID arises if both mutations eliminate ADA activity, whereas a single allele with residual activity can confer a milder phenotype. ADA deficiency accounts for about one-half of cases of autosomal recessive SCID. & In hereditary hemolytic anemia, the level of this enzyme in erythrocytes increases 50-70 times.SIMILARITY: SwissProt: P00813 ## Belongs to the adenosine and AMP deaminases family. View All» Brand Family: Chemicon View All» Product Name: Anti-Adenosine Deaminase Antibody | AB176 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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