货号：AB1786P

品牌：Merck Millipore

规格：50Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dopamine D3 Receptor Antibody, cytoplasmic domain | AB1786P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for Dopamine Receptor D3. Rat Dopamine D3 receptor is a 446 aa, G-protein coupled and transmembrane receptor protein (Giros et al. 1990, 1991; Schmauss et al. 1993; Liu et al. 1994; Fu et al. 1995; Sokoloff et al. 1990; Livingstone et al. 1992). The immunogen peptide shows no significant homology with other dopamine receptors (D1, D2, D4 or D5). SPECIES REACTIVITIES: The immunogen peptide shows sequence homology of 88% with mouse and 63% with human/monkey (12/19 aa) D3 receptors (Giros et al. 1990, 1991; Schmauss et al. 1993; Liu et al. 1994; Fu et al. 1995; Sokoloff et al. 1990; Livingstone et al. 1992). Antibody cross-reactivity with various species is not known. View All» Epitope: cytoplasmic domain View All» Immunogen: A 19 amino acid peptide sequence from the rat D3 receptor within the 3rd cytoplasmic domain. View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western blot: 1-10 μg/mL (Chemiluminescence technique; 45-50 kDa) Approximately 100-400 μg of membrane protein/lane should be loaded to visualize the receptor band. In some systems 70kDa bands may also be present. Immunohistochemistry: suggested working concentration is 2-10 μg/mL. Suggested fixative is 4% PFA, fixation 10-15', permeabilized with 0.3-0.5% triton X-100 for 10-15' (tissue, less time for cels), primary antibody dilution is 1:100 for direct fluorescence . {Coronas, V, et al. J Neurochemistry 91:1292-1301, 2004}, ELISA: 0.5-1.0 μg/mL (1 μg/mL immunogen peptide (Catalog Number AG229)/well) Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS with 0.1% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P35462 View All» Entrez Gene Number:
  • NM_000796.3

  • NM_033663.3
    View All» Gene Symbol:
    • DRD3

    • MGC149204

    • D3DR

    • ETM1

    • MGC149205

    • FET1

    • D
      View All» Alternate Names: D3R View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). View All» UniProt Summary: FUNCTION: SwissProt: P35462 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.SIZE: 400 amino acids; 44225 Da SUBUNIT: Interacts with CLIC6 (By similarity).SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Brain.DISEASE: SwissProt: P35462 # Genetic variation in DRD3 may be associated with susceptibility to hereditary essential tremor 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.SIMILARITY: SwissProt: P35462 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Dopamine D3 Receptor Antibody, cytoplasmic domain | AB1786P View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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