货号：AB1797P

品牌：Merck Millipore

规格：50Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Arginine Vasopressin Receptor V2 Antibody | AB1797P View All» Replaces: AB3512P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Arginine vasopressin receptor (AVP-V2), rat. The peptide used for immunization has no significant similarity with AVP V1a or V1b receptors. View All» Immunogen: 21 amino acid peptide from the 3rd cytoplasmic domain of rat AVP-V2 (Lolait et al. 1992; Fisov et al. 1994). View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1-10 μg/mL using ECL. An antibody raised against this peptide has detected a glycosylated band at ~62 kDa in membranes from rat inner medulla (Nonoguchi et al. 1995). N-Glycanase reduced the size to ~36 kDa (deglycosylated form). Immunohistochemistry: 2-10 μg/mL on paraformaldehyde fixed tissue. AVP-V2 has been localized in terminal IMCD and other areas of rat kidney (Nonoguchi et al. 1995). ELISA: 0.5-1.0 μg/mL using 1 μg/mL of control peptide to coat plate. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P30518 View All» Entrez Gene Number: NM_000054.2 View All» Gene Symbol:

• AVPR2

• DI1

• V2R

• DIR

• MGC138386

• MGC126533

• DIR3

• ADHR

• NDI
  View All» Alternate Names: AVPR-V2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunohistochemistry

  • Western Blotting
    View All» Entrez Gene Summary: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. View All» UniProt Summary: FUNCTION: SwissProt: P30518 # Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.SIZE: 371 amino acids; 40279 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Kidney.DISEASE: SwissProt: P30518 # Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. & Defects in AVPR2 are a cause of X-linked nephrogenic diabetes insipidus, type I (NDI) [MIM:304800]. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria) and fail to concentrate urine in response to vasopressin. Most cases of NDI appear to have an X-linked recessive pattern of inheritance.SIMILARITY: SwissProt: P30518 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Arginine Vasopressin Receptor V2 Antibody | AB1797P View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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