货号：AB1861

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RANK Antibody | AB1861 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: RANK (Receptor Activator of NF-kB). By Western blot AB1861 recognizes a 90 kDa protein. The antibody putatively recognizes amino acids 431-616. RANK is a new member of the tumor necrosis factor receptor superfamily and has an important role in the differentiation of osteoclasts and survival of dendritic cells. View All» Immunogen: GST-RANK intracellular domain, amino acids 235-616. View All» Species Reactivity: Human View All» Application Notes: Western blotting: 1:500-1:2,000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 with 5% skim milk. Suggested incubation time is 1 hour at room temperature. Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y6Q6 View All» Entrez Gene Number: NM_003839.2 View All» Gene Symbol:

• TNFRSF11A

• RANK

• OFE

• ODFR

• CD265

• TRANCER
  View All» Alternate Names: Receptor Activator of NFkappaB View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. View All» UniProt Summary: FUNCTION: SwissProt: Q9Y6Q6 # Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.SIZE: 616 amino acids; 66034 Da SUBUNIT: Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).TISSUE SPECIFICITY: Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.DISEASE: SwissProt: Q9Y6Q6 # Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO) [MIM:174810]. FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early onset deafness and loss of dentition. & Defects in TNFRSF11A are a cause of Paget disease of bone 2 (PDB2) [MIM:602080]; also known as familial Paget disease of bone. PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Unlike FEO, however, affected individuals have involvement of the axial skeleton with lesions in the spine, pelvis and skull.SIMILARITY: SwissProt: Q9Y6Q6 ## Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-RANK Antibody | AB1861 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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