货号：AB1864

品牌：Merck Millipore

规格：

目录价：￥3533.00

市场价格：￥3003.05

会员价格：￥2826.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-4-1BB Antibody | AB1864 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human 4-1BB a member of the tumor necrosis factor receptor superfamily as a co-stimulatory molecule of T cell activation. By Western blot AB1864 recognizes a 29 kDa protein (Reducing and sdenaturuing conditions). Does not cross-react with mouse 4-1BB. View All» Immunogen: GST-4-1BB extracellular domain. View All» Species Reactivity: Human View All» Application Notes: Western blotting: 1:2000-1:5000. ELISA, direct and indirect: 1:2,000-1:10,000. Flow cytometry: 1:1000. Optimal working dilutions must be determined by the end user. FACS Protocol for AB1864 1. wash 0.5 -1.0 X 10(6) cells with FACS buffer (see below) 2 times 2. resuspend cells in 100 μL FACS buffer 3. add 0.5 - 1.0 μL of undiluted AB1864 and incubate on ice for 1 hour for negative control, use pre-immune serum or isotype matched Ig 4. wash 2 times in FACS buffer 5. resuspend in 100 μL FACS buffer and add 0.5 μL secondary antibody-FITC conjugate 6. incubate on ice for 40 min 7. wash 2 times in FACS buffer and resuspend in 500 μL FACS buffer 8. FACS analysis FACS Buffer PBS + 0.2 % BSA + 0.1 % sodium azide Filter through 0.45 μm Keep at 4°C View All» Presentation: Liquid rabbit serum diluted in PBS, pH 7.4. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q07011 View All» Entrez Gene Number: NM_001561.4 View All» Gene Symbol:

• TNFRSF9

• CD137

• 4-1BB

• OTTHUMP00000044294

• MGC2172

• CDw137

• ILA
  View All» Alternate Names: CD137 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. View All» UniProt Summary: FUNCTION: SwissProt: Q07011 # Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation.SIZE: 255 amino acids; 27899 Da SUBUNIT: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed on the surface of activated T-cells.SIMILARITY: SwissProt: Q07011 ## Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-4-1BB Antibody | AB1864 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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