货号：AB1870

品牌：Merck Millipore

规格：100UL

目录价：￥6895.00

市场价格：￥5860.75

会员价格：￥5516.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Osteopontin Antibody | AB1870 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human osteopontin. Does not cross react with osteonectin or human bone sialoprotein II. View All» Molecular Weight: ~35 kDa View All» Immunogen: Synthetic peptide corresponding to amino acids 75-90 of human osteopontin (SwissProt Accession # P10451; PSKSNESHDHMDDM DD). View All» Background Information: Osteopontin is a single-chain polypeptide with a molecular weight of approximately 35 kDa. It is a glycoprotein first identified in osteoblasts. It is biosynthesized by a variety of tissue types including preosteoblasts, osteoblasts, osteocytes, extraosseous cells in the inner ear, brain, kidney, deciduum, placenta, odontoblasts, some bone marrow cells, hypertrophic chondrocytes, macrophages, smooth muscle, and endothelial cells. Osteopontin is overexpressed in a variety of cancers, including lung cancer, breast cancer, colorectal cancer, stomach cancer, ovarian cancer, melanoma and mesothelioma. It may contribute to kidney stone formation and both glomerulonephritis and tubulointerstitial nephritis and is also found in atheromatous plaques within arteries. Research has implicated osteopontin in excessive scar-forming and a gel has been developed to inhibit its effect. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and Mouse. Expected to cross-react with rat. View All» Application Notes: Immunohistochemistry: A previous lot of this antibodu was used at a 1:1500 dilution on paraffin-embedded tissue sections.ELISA: A previous lot of this antibody was used at a 1:1000 dilution.Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: Human urine (2-5 µg/mL normal concentration). View All» Quality Assurance: Routinely evaluated by Western Blot on RAW 264.7 lysates.Western Blot Analysis: 1:500 dilution of this lot detected osteopontin on 10 μg of RAW 264.7 lysates. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal antiserum in buffer containing no preservatives. View All» Storage Conditions: Stable for 1 year at -20°C in undiluted aliquots from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P10451 View All» Entrez Gene Number: NP_000573 View All» Gene Symbol:
  • SPP1

  • BNSP

  • MGC110940

  • Uropontin

  • Nephropontin

  • CIT:779436

  • osteopontin

  • SPP-1

  • BSPI

  • OPN

  • ETA-1
    View All» Alternate Names:
    • Uropontin

    • Bone sialoprotein 1

    • SPP1/CALPHA1 fusion

    • Urinary stone protein

    • bone sialoprotein I

    • osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein

    • secreted phosphoprotein 1

    • secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, earlyT-lymphocyte activation 1)

    • secreted phosphoprotein-1 (osteopontin, bone sialoprotein)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» UniProt Summary: FUNCTION: SwissProt: P10451 # Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).SIZE: 314 amino acids; 35423 Da SUBUNIT: Ligand for integrin alpha-V/beta-3.SUBCELLULAR LOCATION: Secreted.PTM: Extensively phosphorylated on clustered serine residues. & N- and O-glycosylated.DISEASE:SwissProt: P10451 # This protein plays a principal role in urinary stone formation as the stone matrix.SIMILARITY: SwissProt: P10451 ## Belongs to the osteopontin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Osteopontin Antibody | AB1870 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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