货号：AB19001

品牌：Merck Millipore

规格：

目录价：￥4785.00

市场价格：￥4067.25

会员价格：￥3828.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAM 21 Antibody, C-terminus | AB19001 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: ADAM 21 View All» Epitope: C-terminus View All» Immunogen: 13 amino acid synthetic peptide to the carboxy terminal region View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot: (1:1000); 5% purified casein in PBS for blocking. Major unprocessed forms are 100kDa with process forms starting at 90kDa, smaller fragments can be seen as well. Immunocytochemistry: (1:100) Immunohistochemistry: (1:100) ELISA: IP: not tested FACS: Not Suitable Optimal working dilutions must be determined by end user. View All» Applications Not Recommended: Flow Cytometry View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 1% BSA. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: Q9UKJ8 View All» Entrez Gene Number: NM_003813.2 View All» Gene Symbol:
  • ADAM21

  • ADAM31

  • MGC125389

  • EC 3.4.24.-
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene lacks introns and its expression is testis-specific. View All» UniProt Summary: FUNCTION: SwissProt: Q9UKJ8 # May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.COFACTOR: Binds 1 zinc ion per subunit (Potential).SIZE: 722 amino acids; 80820 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: Q9UKJ8 A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding. & The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion. & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain. MISCELLANEOUS: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human. View All» Brand Family: Chemicon View All» Product Name: Anti-ADAM 21 Antibody, C-terminus | AB19001 View All» Concentration: 2 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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